Recently, fast dissolving films are gaining interest as an alternative of fast dissolving tablets. The films are designed to dissolve upon contact with a wet surface, such as the tongue, within a few seconds, meaning the consumer can take the product without need for additional liquid. This convenience provides both a marketing advantage and increased patient compliance. As the drug is directly absorbed into systemic circulation, degradation in gastrointestinal tract and first pass effect can be avoided. These points make this formulation most popular and acceptable among pediatric and geriatric patients and patients with fear of choking. Over-the-counter films for pain management and motion sickness are commercialized in the US markets.
A film is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity, delivering the drug to the systemic circulation via dissolution when contact with liquid is made. Thin-film drug delivery has emerged as an advanced alternative to the traditional tablets , capsules and liquids often associated with prescription and OTC medications. Similar in size, shape and thickness to a postage stamp , thin-film strips are typically designed for oral administration , with the user placing the strip on or under the tongue sublingual or along the inside of the cheek buccal. These drug delivery options allow the medication to bypass the first pass metabolism thereby making the medication more bioavailable.
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